Where would you like to have label free single molecule resolution?
Study proteins and other biomolecules
Mass and optical contrast
For most biological molecules the relation between mass and optical contrast is a linear function. Therefore, our microscope and nanofluidic chips enable direct measurements of single biomolecule mass with an accuracy of 10 kDa.
With our microscope and nanofluidic chips you can determine the diffusion constant of single molecules or other small objects, such as nanoparticles. From here it's easy to calculate their hydrodynamic radius. By tracking them for several seconds the value becomes very accurate and we can reliably distinguish size populations in your sample.
See molecular interactions with your own eyes. Analyse the number of occurrences and their duration to determine binding constants or study molecule-substrate affinity and molecule-molecule interactions. All is possible with our microscope and unique nanofluidic chips.
Use it for quality control
The function of nanoparticles and molecules can change dramatically if aggreagtion occurs. Use our microscope and nanofluidic chips to see if your sample tends to form dimer, trimer or other oligomer aggregates.
Count the number of nanoparticles in your sample. By letting the sample flow through our nanochannels one can count every nanoparticle in the liquid, determine the size and optical contrast.
A versatile research tool
Modify and combine
The microscopy technique can be modified for you needs. Combine with other tools to fit your research. For example add a flow controller to regulate the velocity of molecules moving through the field of view. Or apply a voltage and study how electrical forces affects your molecules. The possibilites to be creative are endless.